Researchers have designed the first “photo-drug” to treat pain that can be specifically activated with light at any moment.
Common pharmacology can limit the therapeutic action of any drug, said researchers, including those from University of Barcelona in Spain.
Using light on a photosensitive drug, the pharmacological process can be controlled with spatial and temporal precision, they said. The drug JF-NP-26 has powerful therapeutic applications to treat pain and can be specifically activated at any moment with light. “In the clinical field, there is not any precedent of the uses of optopharmacology to improve pain treatment or any disease associated with the nervous system.
This is the first light-activated drug designed for the treatment of pain in vivo with animal models,” said Francisco Ciruela, Professor at University of Barcelona.
In the new optopharmacology proposal published in the journal eLife, a drug with a known action mechanism (for example an analgesic) is chemically modified to make it photosensitive and inactive. This drug is activated when receiving light – using an optical fibre of a suitable wave length and with an exact precision on the target tissue (brain, skin, articulations, etc). (PTI)
