Constipation, bloating linked to behavioural issues in autistic kids

New York :  Common gastrointestinal (GI) symptoms such as diarrhoea, constipation and bloating are linked to troubling sleep problems, self-harm and physical complaints in pre-school children especially those with with autism, say researchers.

According to the new study, published in the journal Autism Research, these GI symptoms are much more common and potentially disruptive in young kids with autism.

“This study highlights the link between GI symptoms and some problematic behaviours we see in preschool-aged children,” said study researcher Bibiana Restrepo from the University of California in the US.

Gastrointestinal concerns are frequently reported by parents of children with autism spectrum disorder (ASD).

For the results, the research team evaluated the presence of GI symptoms in preschool-aged children with and without autism.

The study included 255 children with ASD between two and 3.5 years of age and 129 typically developing children in the same age group.

Paediatricians specialising in autism interviewed caregivers during the children’s medical evaluation.

They asked the parents how often their children experienced GI symptoms such as difficulty swallowing, abdominal pain, bloating, diarrhoea, constipation, painful stooling, vomiting, difficulty swallowing, blood in stool and blood in vomit.

The researchers grouped children in two categories: those who experienced one or more GI symptom and those who never or rarely had GI symptoms in the last three months.

They compared the children in the two groups on measures of developmental, behavioural and adaptive functioning.

The study found that preschool-aged children with ASD were 2.7 times more likely to experience GI symptoms than their typically developing peers.

In fact, almost 50 per cent of children with ASD reported frequent GI symptoms – compared to 18 per cent of children with typical development.

The findings showed that around 30 per cent of the children with ASD experienced multiple GI symptoms.

Multiple GI symptoms were associated with increased challenges with sleep and attention, as well as problem behaviours related to self-harm, aggression and restricted or repetitive behaviour in both autistic and typically developing children.

The severity of these problems was higher in children with autism.

“Problem behaviours may be an expression of GI discomfort in preschool-aged children,” the study authors wrote.

“GI symptoms are often treatable, so it is important to recognize how common they are in children with autism. Treating their GI symptoms could potentially provide some relief to the kids and their parents,” they noted.

Mother’s obesity may interfere with child’s brain

Obesity in expectant mothers may be a contributing factor in hindering the development of the babies’ brains, according to a new study.

Led by researchers at NYU Grossman School of Medicine, the investigation linked high body mass index (BMI), an indicator of obesity, to changes in two brain areas, the prefrontal cortex, and anterior insula. These regions play a key role in decisionmaking and behaviour, with disruptions having previously been linked to attentiondeficit/hyperactivity disorder (ADHD), autism and overeating.

In their new study, publishing online today (August 11) in the Journal of Child

Psychology and Psychiatry, the investigators examined 197 groups of metabolically active nerve cells in the fetal brain. Using millions of computations, the study authors divided the groups into 16 meaningful subgroups based on over 19,000 possible connections between the groups of neurons.

They found only two areas of the brain where their connections to each other were statistically strongly linked to the mother’s BMI.

“Our findings affirm that a mother’s obesity may play a role in fetal brain development, which might explain some of the cognitive and metabolic health concerns seen in children born to mothers with higher BMI,” said Moriah Thomason,

PhD, the Barakett Associate Professor in the Department of Child and Adolescent Psychiatry at NYU Langone Health.

As obesity rates continue to soar in the United States, it is more important than ever to understand how the condition may impact early brain development, says Thomason, who is also an associate professor in the Department of Population Health at NYU Langone.

Previous studies showing an association between obesity and brain development had mostly looked at cognitive function in children after birth. The new investigation is believed to be the first to measure changes in fetal brain activity in the womb and as early as six months into pregnancy.

Thomason says this approach was designed to eliminate the potential influence of breastfeeding and other environmental factors occurring after birth and to examine the earliest origins of negative effects of maternal BMI on the developing child’s brain. (ANI)



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